PAUL DAVID JAMES BLACKLER,ANDREW SIMON CRAIG,ROBERT GORDON GILES,MICHAEL JOHN JOHN SASSE
申请号：
INPCT/2001/00964/DEL
公开号：
IN2001DN00964A
申请日:
2001.10.19
申请国别(地区):
IN
年份:
2013
代理人:
摘要：
A process for preparing 5-[4-[2-(N-methyl-N-(2- pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione hydrochloride monohydrate, wherein (a) a suspension of 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione, Compound (I) is treated with a source of hydrochloride ions such as herein described in an aqueous organic solvent such as herein described at a temperature in the range of from 20°C to 30°C and an appropriate amount of water in the range of from 2 to 10% (b) a solution of Compound (I) is treated with a source of hydrochloride ions in acetic acid as solvent preferably crystallization is then induced to provide the Hydrochloride monohydrate and thereafter the required compound is recovered.
