Elena Burova,Alexander O. Mujica,Ka-Man Venus Lai,Andrew J. Murphy
申请号：
US14744592
公开号：
US09955677B2
申请日:
2015.06.19
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Non-human animals, and methods and compositions for making and using the same, are provided, wherein the non-human animals comprise a humanization of a Programmed cell death 1 (Pdcd1) gene. The non-human animals may be described, in some embodiments, as having a genetic modification to an endogenous Pdcd1 gene so that the non-human animals express a PD-1 polypeptide that includes a human portion and an endogenous portion (e.g., a non-human portion).
