An intravenous splint cover may include a main body and a pair of opposing securing members connected to the main body. The intravenous splint cover may also include a splinting member carried by the main body to create an elevated portion of the main body. Bottom portions of the pair of opposing securing members and the main body that does not carry the splinting member may have an adhesive material applied thereto. The splinting member may extend along a medial portion of the bottom portion of the main body substantially between an entire width thereof. The intravenous splint cover according to the present invention advantageously secures an IV site of a patient while allowing the extremity of the patient with IV is located to remain mobile.