CHONG KUN DANG PHARMACEUTICAL CORP.;NATIONAL CANCER CENTER
发明人:
Soo Jin Kim,Young Sang Kim,MinChae Kim,Young-Whan Park,Jung-Yong Kim,In Chull Kim
申请号：
US15447247
公开号：
US09980953B2
申请日:
2017.03.02
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present invention relates to a pharmaceutical combined composition for preventing or treating cancer comprising a compound of formula 1 or a pharmaceutically acceptable salt thereof and topoisomerase inhibitor as active ingredients. The pharmaceutical combined composition of the present invention specifically inhibits cell proliferation and induces apoptosis as to various cancers such as colorectal cancer and ovarian cancer that a vascular disrupting agent cannot treat due to a complex inhibition mechanism of neoplasm of the compound of formula 1 and the pharmaceutically acceptable salt thereof and topoisomerase inhibitor, and thereby it can be usefully used for preventing and treating cancer.
