Methods and compositions to generate and control the effector profile of T cells by simultaneous loading and activation of selected subsets of antigen presenting cells
Lilin Wang;William Joseph Phillips, Jr.;Luis A. Dellamary;Adrian Bot;Dan Joseph Smith
发明人:
Adrian Bot,Lilin Wang,Dan Joseph Smith,William Joseph Phillips, Jr.,Luis A. Dellamary
申请号：
US13078119
公开号：
US08809290B2
申请日:
2011.04.01
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention is directed to novel compositions that cause effective redirection of class I-immunity to Tc1 effectors, that take advantage of the unexpected loading of MHC I by peptide within IgG backbone combined with appropriate instruction of antigen presenting cells. Such compositions are able to transform a seemingly ineffective therapeutics into a highly effective one, associated with generation of class I-restricted cytolytic cells and IFN-γ, IL-2 producing T cells, further associated with protection against a highly virulent microbe or recovery from malignant tumoral process.
