Provided herein is an ophthalmic composition, in particular for stabilization of the lacrimal film, corneal cicatrization, restoration of the saline content of the tear, and osmoprotection, comprising an aqueous solution of cobalamine, sodium hyaluronate, and other substances that by acting synergistically are able to stabilize chemically cobalamine at a pH in the 6.0-7.5 range, ensuring an excellent ocular tolerability.