A system for manipulation of a tissue sample includes a chassis, a chamber defined in the chassis and configured to receive and retain a complimentary device including a sample processing compartment disposed between sheets of a flexible material and a waste chamber disposed between the sheets of the flexible material. The complimentary device is configured to retain the tissue sample during manipulation of the tissue sample by the system. A fluid mixing sub-system is configured to agitate and mix a fluid including the tissue sample within the sample processing compartment. A temperature control sub-system including at least one of a first heating element and a first cooling element is configured and arranged to be in thermal communication with the sample processing compartment. An electronic controller is in communication with, and programmed to control operation of the fluid mixing sub-system and the temperature control sub-systems.
