THE GENERAL HOSPITAL CORPORATION;MASSACHUSETTS INSTITUTE OF TECHNOLOGY
发明人:
Suraj J. Patel,John M. Milwid,Martin L. Yarmush,Kevin R. King
申请号：
US15414001
公开号：
US20170128475A1
申请日:
2017.01.24
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The present embodiments relate to compositions and methods for treating the inflammatory response in a tissue or organ, such as the liver, by contacting the tissue with a tissue-specific gap junction inhibitor； and compositions and methods of reducing the toxicity of an agent by administering a gap junction inhibitor either simultaneously or sequentially with exposure to the agent. For example, inhibition of the liver-specific gap junction connexin 32 by 2-aminoethyoxydiphenyl-borate, effectively treats and/or prevents hepatotoxicity.
