YU, ALICE L.,陈铃津,陳鈴津,LIN, WEN-DER,林文德,HUNG, JUNG-TUNG,洪荣堂,洪榮堂,FAN, TAN-CHI,范丹琪
申请号：
TW106126196
公开号：
TW201825673A
申请日:
2017.08.03
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
The present invention relates to modified cancer cell lines, wherein the ST3Gal1 glycosyltransferase expression is reduced or inhibited. The use of the modified cancer cell lines with suppressed ST3Gal1 glycosyltransferase to screen a potential cancer therapeutic is provided. The suppression of ST3Gal1 glycosyltransferase expression, with or without an anti-cancer agent is also provided to inhibit the growth of cancer cells in a subject.本發明關於一種修飾的癌細胞株，其中ST3Gal1醣基轉移酶表現被降低或抑制。提供抑制ST3Gal1醣基轉移酶的修飾癌細胞株篩選潛在癌症治療劑的用途。也提供ST3Gal1醣基轉移酶表現的抑制(具有或沒有抗癌劑)以抑制個體中的癌細胞生長。
