The present invention is a method for treating, preventing, reversing, arresting or inhibiting the occurrence, development and maturation of seizures or seizure-related disorders. More specifically, the present invention is directed to uses of benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as described herein for the manufacture of a medicament to therapeutically or prophylactically treat, prevent, reverse, arrest or inhibit epileptogenesis and epilepsy.本發明是一種供治療、預防、逆轉、遏止或抑制癲癇發作或癲癇發作-相關疾病的發生、發病及成熟之方法。更特別地,本發明有關具有如此處所述之化學式(I)以及化學式(Π)的新穎苯并-稠合環磺醯胺衍生物的用途,其供製造一治療性地或預防性地治療、預防、逆轉、遏止或抑制癲癇產生或癲癇的醫藥物。