System of the present invention provides a kind of biological monitor and its operating method for having zero offset capability,The biological monitor system includes: device noumenon,It include outside operation display interface,Test piece plugs the circuit module and battery pack of portion and inside,The battery system use for should circuit module running institute must electric power,Then use the test piece insert group cooperation for making a reservation for a variety of patterns in the test piece portion of plugging; Test piece data stores mould group,It uses for a variety of test piece related datas of storing memory; Mould group is automatically corrected,With test piece plug portion,Test piece data stores mould group and circuit module electrical connection,The electrical value of test piece that detecting test piece plugs portion is used,And closed automatically with the deposited data matchmaker of test piece data storage mould group,The detection formula referential data of multiple automatic calibration circuit mould group,Thereby to ensure the detection precision of biological monitor,Thereby design,Enable biological monitor using above can directly insert group test piece detected,Cipher chips or input correcting code need not be used,Reach and uses more easy handy practical improvement.本發明係提供一種具自動校正功能之生物檢測裝置及其操作方法,所述生物檢測裝置係包含:裝置本體,其包括外部之操作顯示界面、試片插設部以及內部之電路模組及電池組,該電池組係藉以供應該電路模組運作所須電力,該試片插設部則藉以供預定多種型式之試片插組配合;試片資料儲存模組,藉以供儲存記憶多種試片相關資料;自動校正模組,與試片插設部、試片資料儲存模組及電路模組電性連結,藉以偵測試片插設部之試片電性值,並自動與試片資料儲存模組所存資料媒合,復自動校正電路模組之檢測程式參考數值,藉此以確保生物檢測裝置之檢測精準度,藉此設計,令生物檢測裝置使用上可直接插組試片進行檢測,無須使用密碼片或輸入校正碼,達到使用更加簡便好用之實用進步性。