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SPIROCYCLIC ISOXAZOLINE DERIVATIVES AS ANTIPARASITIC AGENTS
专利权人:
ZOITIS EHLEHLSI
发明人:
BILLEN DENIS,БИЛЛЕН Денис,CHABB NEHTEHN EHNTONI LOGAN,ЧАББ Нэтэн Энтони Логан,KERTIS MAJKL,КЕРТИС Майкл,GRINVUD SHON DIDABLJU,ГРИНВУД Шон ДиДаблЮ,MENON SANDZHAJ,МЕНОН Санджай,STAK TIMOTI,СТАК Тимоти,V
申请号:
RU2013139630
公开号:
RU2566083C2
申请日:
2012.02.23
申请国别(地区):
RU
年份:
2015
代理人:
摘要:
FIELD: chemistry.SUBSTANCE: invention relates to a spirocyclic isoxazoline derivative of formulawhere each of Y and Z is C each of W, Wand Wis C A together with Y and Z is a 5-member heterocyclic ring, wherein said heterocyclic ring contains 1 heteroatom selected from N and O, and wherein the ring A is optionally substituted with at least one substitute selected from oxo and C-Calkyl each of R, Rand Ris independently hydrogen, halogen or C-Chaloalkyl Ris C-Chaloalkyl Ris -C(O)R Ris C-Calkyl, C-CalkylC-Ccycloalkyl, C-Calkylheteroaryl, where said heteroaryl is pyrazolyl, or C-Calkylheterocycle, where said heterocycle is thietanyl each C-Calkyl or C-CalkylC-Ccycloalkyl group of Rcan be optionally and independently substituted with at least one substitute selected from halogen, hydroxyl, C-Chaloalkyl, C-Calkyl, hydroxylC-Calkyl- and -S(O)Rgroups and each C-Calkylheteroaryl or C-Calkylheterocyclic group of Rcan optionally be further substituted with at least one substitute selected from oxo and C-Calkyl Ris C-Calkyl or C-Chaloalkyl n equals 0 p equals 0, 1 or 2 andis a single or double bond stereoisomers thereof and veterinary-acceptable salts thereof. The invention also relates to spirocyclic isoxazoline derivatives of formulaand specific derivatives thereof. Spirocyclic isoxazoline derivatives are used in the production of veterinary compositions having antiparasitic action against ectoparasites for treating ectoparasite infection or invasion in animals.EFFECT: invention relates to a method of producing a compound of formulaand specific compounds used as intermediate compounds when producing the desired compounds.23 cl, 4 tbl, 9 exИзобретение относится к спироциклическому производному изоксазолина формулы (V.1), где каждый из Y и Z представляет собой С каждый из W, Wи Wпредставляет собой С А вместе с Y и Z представляет собой 5-членное гетероциклическое кольцо, причем это гетероциклическое кольцо содержит 1 гетероатом, выбранный из N или О, и при этом кольцо А возможно
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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