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Improved drug delivery by conjugating oligonucleotides to stitched/stapled peptides
专利权人:
Sutura Therapeutics Ltd
发明人:
Keith Foster
申请号:
GB201912318
公开号:
GB2574525B
申请日:
2015.12.21
申请国别(地区):
GB
年份:
2020
代理人:
摘要:
Improvements in drug delivery and more particularly to the use of Cell Penetrating Agents (CPA’s) or Cell Penetrating Peptides (CPP’s) which have been stabilized by, for example: i) stapling two amino acids to form Stapled CPP’s (StaP’s) or ii) stitching three or more amino acids to form stitched CPP’s (StiP’s) are claimed. Said CPP’s are conjugated to a drug or Biologically Active Compound (BAC) directly or via a Bi-Functional Linker (BFL) so that the BAC can be carried though a cell membrane by the CPP. The resulting molecules are referred to as Drug Carrying Cell Penetrating Molecules (DCCPM’s). The preferred BAC is an electrically low charge carrying oligonucleotide such as a phosphorodiamate morpholino oligonucleotide (PMO). Said methods can be used the treatment of diseases a or genetic conditions. .
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/
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