DIAS REMETH JACKY,MALI KAILAS KRISHNAT,GHORPADE VISHWAJEET SAMPATRAO,BAGAL PRAVIN VASANTRAO
申请号：
IN3009/MUM/2012
公开号：
IN2012MU03009A
申请日:
2012.10.15
申请国别(地区):
IN
年份:
2012
代理人:
摘要：
Migraine is usually associated with recurrent headaches, anorexia, gastric stasis, nausea and vomiting. The analgesics which are administered to reduce the pain during migraine are poorly absorbed due to gastric stasis. Hence the formulation used for the treatment of migraine must relieve the pain and the associated symptoms. The present invention is related to a bilayer tablet comprising an immediate release first layer containing an effective amount of a prokinetic agent, granisetron hydrochloride, and a sustained release second layer containing an effective amount of nonsteroidal anti-inflammatory agent, diclofenac sodium, along with the pharmaceutically acceptable ingredients. The formulation shows an immediate release of granisetron hydrochloride from the first layer followed by sustained release of diclofenac sodium for a period of 8 hrs. Thus the bilayer tablet of granisetron hydrochloride and diclofenac sodium may be efficient in treatment of migraine and associated symptoms followed by reduction in dosing frequency.
