RIKEN;Sumitomo Dainippon Pharma Co., Ltd.;SUMITOMO CHEMICAL COMPANY, LIMITED
发明人:
申请号:
EP18856535.2
公开号:
EP3683306A1
申请日:
2018.09.14
申请国别(地区):
EP
年份:
2020
代理人:
摘要:
The present invention aims to provide a method for suppressing differentiation of ganglion cell, amacrine cell, horizontal cell and/or bipolar cell in a neural retina tissue containing photoreceptor precursor and/or photoreceptor, and the like. A method for suppressing differentiation of a ganglion cell, an amacrine cell, a horizontal cell and/or a bipolar cell in a neural retinal tissue containing a photoreceptor precursor and/or a photoreceptor, including a step of culturing a retinal tissue comprising a neural retinal progenitor cell and in any stage between a differentiation stage immediately after emergence of a ganglion cell and a differentiation stage where emergence rate of a cone photoreceptor precursor reaches maximum in a medium containing a thyroid gland hormone signal transduction pathway agonist.