Erik Jordahl Forsberg;Kathryn Margaret Nelson;Michael William Mosesson;Anthony Pusateri
发明人:
Kathryn Margaret Nelson,Michael William Mosesson,Anthony Pusateri,Erik Jordahl Forsberg
申请号：
US13582044
公开号：
US09546381B2
申请日:
2011.03.11
申请国别(地区):
US
年份:
2017
代理人:
摘要：
The invention relates to the production of recombinant human fibrinogen (rhFib) in the milk of transgenic mammalian animals. This production and subsequent purification process is generally hampered by the occurrence of so-called ‘clots’ and ‘flakes’ in the milk which, in severe cases, may prevent the cow from being milked at all, resulting in a halt of lactation. These clots and flakes occur because of the expression of the fibrinogen protein, which is a factor that is normally involved in blood clotting. The invention relates to solving this milk clotting problem by treating the (lactating) animals with anticoagulants such as coumarins. A preferred anticoagulant that is used in the methods of the present invention is warfarin.
