A silane-QAC-dendritic polymer biocide surface treatment for bath, screen or spray- on application. The silane-QAC-dendritic polymer biocide generally comprises a highly branched polymer modified to include quaternary ammonium compounds for biocidal activity, and further modified to include a functionalized silane moiety to covalently attach the polymer biocide to a variety of substrates through hydrolysis. The highly branched polymer may be any one from among a group consisting of dendrimers, dendritic polymers, and hyperbranched polymers, and the functionalized silane moiety may be Siloxane (- Si(OR)3). The resulting surface treatment combines the demonstrated high potency of quaternary ammonium compound dendrimers and hyperbranched polymers with the well- 5 established coupling chemistry of silane functional groups. Upon hydrolysis, the silane groups will covalently attach to functional groups such as amines and hydroxyl groups. This provides an effective biocidal surface treatment for any substrates having exposed hydroxyl, amine or other suitable reactive groups.