A physiological signal measuring method and a physiological signal measuring device are provided. The physiological signal sensing method includes the following steps: A first inputting signal having a first frequency, a second inputting signal having a second frequency and a third inputting signal having a third frequency are respectively inputted to at least two electrode sheets attached on a skin. A first impedance value corresponding the first inputting signal, a second impedance value corresponding the second inputting signal and a third impedance value corresponding the third inputting signal are respectively measured. An interference impedance between the electrode sheets and the skin is obtained according to the first frequency, the second frequency, the third frequency, the first impedance value, the second impedance value and the third impedance value. A measured physiological signal is corrected according to the interference impedance, such that a corrected physiological signal is obtained.一種生理訊號量測方法及生理訊號量測裝置。生理訊號量測方法包括以下步驟：分別以一第一輸入訊號、一第二輸入訊號及一第三輸入訊號輸入至一皮膚上之至少二電極片。第一輸入訊號具有一第一頻率，第二輸入訊號具有一第二頻率，第三輸入訊號具有一第三頻率。分別量測對應於第一輸入訊號、第二輸入訊號及第三輸入訊號之一第一阻抗值、一第二阻抗值及一第三阻抗值。依據第一頻率、第二頻率、第三頻率、第一阻抗值、第二阻抗值及第三阻抗值，獲得此些電極片與皮膚之間的一干擾阻抗。依據干擾阻抗，校正一量測生理訊號，以獲得一已校正生理訊號。
