There is disclosed a transdermal composition comprising from about 0.1 to 25% by weight of a piroxicam-inorganic material complex composed of a swellable clay and piroxicam intercalated between layers thereof, from about 50 to 80% by weight of an adhesive polymeric material, and from about 0.1 to 25% by weight of an absorption enhancer. There is further disclosed a transdermal patch system comprising the subject transdermal composition. In the transdermal composition, piroxicam is dispersed on a molecular level between layers of a clay material. As a result, the dispersability, stability and solubility of the piroxicam are improved, the recrystallization of the piroxicam is prevented, and excellent absorption properties and skin permeability of the piroxicam are achieved. Therefore, excellent anti-inflammatory and analgesic effects are exhibited, little or no skin irritation is caused, thereby preventing occurrence of side effects, and the active ingredient is continuously administered by a transdermal route.
