您的位置: 首页 > 农业专利 > 详情页

MEANS FOR TREATMENT OF KIDNEY KIDNEYS
专利权人:
НИТТО ДЕНКО КОРПОРЕЙШН (JP)
发明人:
НИИТСУ Еширо (JP),КАДЖИВАРА Кейко (JP),ТАНАКА Ясунобу (JP),МИЯЗАКИ Мийоно (JP)
申请号:
RU2013101969/15
公开号:
RU2013101969A
申请日:
2011.06.17
申请国别(地区):
RU
年份:
2014
代理人:
摘要:
1. A carrier for delivering a substance to extracellular matrix-producing cells in the kidney, characterized in that it contains a retinoid as an agent targeting extracellular matrix-producing cells in the kidney. The carrier according to claim 1, characterized in that the retinoid contains retinol. The carrier according to claim 1 or 2, characterized in that it has the form of a liposome and the molar ratio of retinoid to lipid contained in the liposome is from 8: 1 to 1: 4.4. A pharmaceutical composition for treating kidney fibrosis, characterized in that it contains a carrier according to any one of claims 1 to 3 and a drug for controlling the activity or growth of extracellular matrix-producing cells in the kidney. The pharmaceutical composition according to claim 4, characterized in that the drug for controlling the activity or growth of the extracellular matrix cells in the kidney is selected from the group consisting of an inhibitor of the activity or production of PAI-1, an inhibitor of cell activity, a growth inhibitor, an apoptosis inducer and an RNAi molecule , ribozyme, antisense nucleic acid or DNA / RNA of a chimeric polynucleotide that targets at least one of the molecules that make up the extracellular matrix, or molecules involved in the production of the formation or secretion of the molecules that make up the extracellular matrix, or the vector expressing them. 6. The pharmaceutical composition according to claim 4, characterized in that the drug for controlling the activity or growth of extracellular matrix producing cells is an HSP47.7 inhibitor. A pharmaceutical composition according to any one of claims 4 to 6, characterized in that the drug and carrier are mixed in place to treat1. Носитель для доставки вещества к продуцирующим внеклеточный матрикс клеткам в почке, отличающийся тем, что он содержит ретиноид в качестве агента, нацеливающего на продуцирующие внеклеточный матрикс клетки в почке.2. Носитель по п.1, отличающийся тем, что ретиноид
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充