A novel synthetic route providing one pot autocatalysed synthesis of dihydropyrimidone derivatives of Formula 1 and 2. The process comprising the steps of reacting ethylaceotacetate, p-carboxybenzaldehyde and urea to yield an intermediate dihydropyrimidone with benzoic acid functionality, having the structure of Formula 3 reacting the said intermediate with a moiety of isocyanide and a moiety of aldehyde in methanol to result in five component dihydropyrimidone derivatives i.e. Formula1 and/or reacting the said intermediate with a moiety of isocyanide and a moiety of aldehyde in methanol and aniline to result in six component dihydropyrimidone derivatives i.e. Formula 2.
