醫藥組合农业专利-农业专业知识服务系统

发明人:: BINASCHI, MONICA,宾纳斯奇　莫妮卡,賓納斯奇　莫妮卡,BIGIONI, MARIO,毕吉欧尼　马力欧,畢吉歐尼　馬力歐,MERLINO, GIUSEPPE,梅利诺　吉斯普,梅利諾　吉斯普,SIMONELLI, CECILIA,席梦利　赛席拉,席夢利　賽席拉,BERTONI, FRANCESCO,柏托尼　法兰西斯柯,柏托尼　法蘭西斯柯,PELLACANI, ANDREA,佩拉卡尼　安,宾纳斯奇莫妮卡,賓納斯奇莫妮卡,毕吉欧尼马力欧,畢吉歐尼馬力歐,梅利诺吉斯普,梅利諾吉斯普,席梦利赛席拉,席夢利賽席拉,柏托尼法兰西斯柯,柏托尼法蘭西斯柯,佩拉卡尼安

摘要：: The present disclosure relates generally to the fields of immunology and molecular biology. More specifically, provided herein are pharmaceutical combinations comprising (A) antibodies, or antigen-binding portions thereof, directed against LY75, and (B) a second anti-cancer entity； nucleic acids encoding antibody combinations； methods for preparing antibody combinations； and methods for the treatment of diseases, such as cancers mediated by LY75 expression or activity.本發明大體上係關於免疫學及分子生物學領域。更特定言之，本發明提供包含 (A)針對LY75之抗體或其抗原結合部分及(B)第二抗癌實體之醫藥組合；編碼抗體組合之核酸；製備抗體組合之方法；以及治療諸如由LY75表現或活性介導之癌症的疾病之方法。