Da Costa, Silvia R.;Fast, David J.;Murray, Mary A.;Lin, Yumei;Roh-schmidt, Haeri;Wilkins, Leon M.;Krempin, David W.;Rebhun, John F.;Gellenbeck, Kevin W.;Rana, Jatinder
发明人:
申请号：
EP11176493.2
公开号：
EP2415469A1
申请日:
2007.10.24
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
Disclosed herein are dietary supplement compositions, regimens and methods for increasing or stimulating bone growth, decreasing or preventing bone resorption, increasing bone strength, improving bone structure, and improving bone architecture comprising a first composition comprising a combination of at least two of: quercetin, Siberian ginseng, Sophora japonica, and licorice, wherein the combination of the first composition increases bone morphogenic protein-2 gene, promoter or protein expression； and a second composition comprising an extract of pomegranate in combination with at least one of green tea, grape seed, and ipriflavone, wherein the combination of the second composition inhibits the expression of RANK-L.
