KALA PHARMACEUTICALS, INC.;KALA PHARMACEUTICALS, INC.
发明人:
ALEXEY POPOV,ALEXEY POPOV,ELIZABETH M. ENLOW,ELIZABETH M. ENLOW,HONGMING CHEN,HONGMING CHEN
申请号：
BR112014027296
公开号：
BR112014027296A2
申请日:
2013.05.03
申请国别(地区):
BR
年份:
2017
代理人:
摘要：
Particles, compositions, and methods that aid particle transport in mucus are provided. The particles, compositions, and methods may be used, in some instances, for ophthalmic and/or other applications. In some embodiments, the compositions and methods may involve modifying the surface coatings of particles, such as particles of pharmaceutical agents that have a low aqueous solubility. Such compositions and methods can be used to achieve efficient transport of particles of pharmaceutical agents though mucus barriers in the body for a wide spectrum of applications, including drug delivery, imaging, and diagnostic applications. In certain embodiments, a pharmaceutical composition including such particles is well-suited for ophthalmic applications, and may be used for delivering pharmaceutical agents to the front of the eye and/or the back of the eye.
