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DIVERSION-RESISTANT MICROGRANULES AND MICROTABLETS
专利权人:
Vincent Billoet
发明人:
Vincent Billoet
申请号:
US13702787
公开号:
US20130129825A1
申请日:
2011.06.07
申请国别(地区):
US
年份:
2013
代理人:
摘要:
The invention relates to the use of an oral dosage form based on microgranules and/or microtablets to reduce the abusive use of at least one active principle contained therein. The aim of the invention is to prevent the diversion of an oral dosage form based on microgranules and/or microtablets containing at least one active principle capable of causing a dependency, a gelling agent, and a gelling activator. The gelling agent and the activator are only brought into contact with each other in the event of diversion by crushing. Said judiciously selected pair of excipients confers a viscosity to the formulation, such that said formulation cannot be administered by injection or does not release the active principle rapidly by forming a gel when it comes into contact with the mucous membrane if nasally administered.
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