HØGSET, Anders,WALDAY, Per Edvard,EIVINDVIK, Kristin
申请号：
EPEP2014/068236
公开号：
WO2015/028541A1
申请日:
2014.08.28
申请国别(地区):
EP
年份:
2015
代理人:
摘要：
A device (1) for activating light-induced rupture of endocytic vesicles in target cells of a patient so as to effect delivery of an administered antigen to cytosol in the target cells, is described. The device is adapted to be worn by a patient over a region of skin where an antigen and a photosensitising agent have been or are to be administered. The device comprises a rear surface (11) that is rounded or otherwise configured to be worn against the patient's skin. It has a retaining part for retaining the device in place over the region of the patient's skin during an activation cycle, which may be a strap (3a, 3b) or an adhesive layer. A light source, such as an LED, is arranged to illuminate the patient's skin from the rear of the device. A control system is configured to vary the output of the light source with respect to time in accordance with a pre-configured output sequence, which includes an initial stage where the output of the light source is set to be zero or generally below that which could deliver a light dose that can activate light-induced rupture of endocytic vesicles (so as to allow time for the antigen and photosensitising agent to reach the target cells), and a later stage where the output is set to deliver a light dose which can activate light-induced rupture of the endocytic vesicles (for effecting the delivery of the administered antigen to the cytosol of the target cells).L'invention concerne un dispositif (1) destiné à activer une rupture induite par lumière de vésicules endocytiques dans des cellules cibles d'un patient, de façon à réaliser l'administration, dans le cytosol des cellules cibles, d'un antigène administré. Le dispositif est apte à être porté par un patient sur une région de la peau où un antigène et un agent photosensibilisant ont été administrés ou sont destinés à être administrés. Le dispositif comprend une surface arrière (11) qui est arrondie ou par ailleurs conçue pour être portée contre la peau du patient. Il comprend un
