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SALMONELLA PARATYPHI A À CHAÎNE HYDROCARBONÉE D'ANTIGÈNE O ALLONGÉE ET UTILISATION ASSOCIÉE
专利权人:
Institute of Biotechnology; Academy of Military Medical Sciences; China
发明人:
申请号:
EP15867235.2
公开号:
EP3231868A1
申请日:
2015.09.07
申请国别(地区):
EP
年份:
2017
代理人:
摘要:
The present invention discloses a Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain and uses thereof. The method comprises the following steps: inactivating an cld gene encoding an enzyme controlling chain length of O-antigen of a Salmonella paratyphi A strain to obtain a Salmonella paratyphi A with deletion of cld gene; allowing overexpression of cldLT2 gene encoding an enzyme controlling chain length of O-antigen of Salmonella typhimurium in Salmonella paratyphi A deficient in the cld gene encoding an enzyme controlling chain length of O-antigen, so as to extend carbohydrate chain length of O-antigen. Both of the Salmonella paratyphi A O-polysaccharide-recombinant fusion protein conjugate vaccines rCTB45733-OPSSpty50973 and rEPA4573-OPSSpty50973 as prepared by using Salmonella Paratyphi A with an O-antigen having an extended carbohydrate chain can induce mice to generate specific antibodies against Salmonella paratyphi A, and their antibody titers are significantly improved.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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