Subgroup B recombinant human adenovirus vector, and methods for constructing and for using the same

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专利权人:

发明人:

Yaohe Wang,Guozhong Jiang,Hanshi Wong,Fengyu Cao,Nick Lemoine

申请号：

US14093078

公开号：

US09315827B2

申请日:

2013.11.29

申请国别(地区):

US

年份:

2016

代理人:

摘要：

A method for constructing a subgroup B recombinant human adenovirus vector Ad11-5EP. The method includes substituting a 365 bp fragment including an enhancer and a promoter of an upstream coding sequence of Ad5 E1A for a corresponding region of a serotype Ad11 of the subgroup B human adenovirus vector by homologous recombination to construct the subgroup B recombinant human adenovirus vector Ad11-5EP. A subgroup B recombinant human adenovirus vector Ad11-5EP constructed by the method and the use thereof for treatment of tumors are also provided.

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