ADULT STEM CELL LINE INTRODUCED WITH HEPATOCYTE GROWTH FACTOR GENE AND NEUROGENIC TRANSCRIPTION FACTOR GENE WITH BASIC HELIX-LOOP-HELIX MOTIF AND USES THEREOF
AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION
发明人:
Hae Young Suh,Sung Soo Kim,Seung Wan Yoo,Young Don Lee
申请号：
US16688434
公开号：
US20200190535A1
申请日:
2019.11.19
申请国别(地区):
US
年份:
2020
代理人:
摘要：
The present invention relates to an adult stem cell line introduced with an HGF gene and a neurogenic transcription factor gene of a bHLH family, a preparation method of the adult stem cell line, a composition for the prevention or treatment of neurological diseases comprising the adult stem cell line, and a method for treating neurological diseases comprising the step of administering the composition to a subject having neurological diseases or suspected of having neurological diseases. The adult stem cells according to the present invention, which are introduced with an HGF gene and a neurogenic transcription factor gene of a bHLH family, can be used to overcome chronic impairment caused by cell death following stroke. Thus, the adult stem cells can be developed as a novel therapeutic agent or widely used in clinical trial and research for cell replacement therapy and gene therapy that are applicable to neurological diseases including Parkinson's disease, Alzheimer disease, and spinal cord injury as well as stroke.
