III;Harry A. Dugger, III;Harry A. Dugger;Mohammed Abd El-Shafy
发明人:
Harry A. Dugger, III,Mohammed Abd El-Shafy
申请号：
US12576457
公开号：
US08236285B2
申请日:
2009.10.09
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Buccal aerosol sprays or capsules using polar and non-polar solvents have now been developed which provide zolpidem for rapid absorption through the oral mucosa, resulting in fast onset of effect. The buccal polar compositions of the invention comprise formulation I: aqueous polar solvent, zolpidem, and optional flavoring agent； formulation II: aqueous polar solvent, zolpidem, optionally flavoring agent, and propellant； formulation III: non-polar solvent, zolpidem, and optional flavoring agent； formulation IV: non-polar solvent, zolpidem, optional flavoring agent, and propellant； formulation V: a mixture of a polar solvent and a non-polar solvent, zolpidem, and optional flavoring agent； formulation VI: a mixture of a polar solvent and a non-polar solvent, zolpidem, optional flavoring agent, and propellant.
