LOW, Philip S.,LOW, Stewart A.,NIELSEN, Jeffery Jay Howard
申请号：
EP17875427
公开号：
EP3548012A4
申请日:
2017.11.30
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Disclosed herein includes a drug delivery system comprising at least one peptide and a targeting ligand for bone fracture and/or for bone healing. Some embodiments include a peptide delivery system comprising at least an acidic, basic, hydrophilic, hydrophobic or neutral peptide linked to an acidic peptide or nonpeptidic polyanion for use in targeting the aforementioned attached peptide to a bone fracture surface. In some embodiments, a conjugated peptide expresses an anabolic function that acts through PTH receptor 1, and various formats of targeting ligands guide the drug to raw hydroxyapatite. This system offsets some side effects caused by free anabolic drug, such as high blood calcium concentration
