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Porous tissue scaffolds
专利权人:
发明人:
VAN BOXTEL, Huibert
申请号:
ES12784651
公开号:
ES2624653T3
申请日:
2012.10.31
申请国别(地区):
ES
年份:
2017
代理人:
摘要:
A method for producing a porous material from a liquid solution comprising a biocompatible polymer, the method comprising: a. introducing the biocompatible polymer solution into a thermally insulated container with a thermally conductive surface; b. optionally, allowing at least part of the biocompatible polymer solution to gel, cooling the vessel in a cooling device at a temperature in the range from the melting point of the sample (Tm) to 25 ° C; c. freeze the gel / biocompatible polymer solution in a controlled manner through the thermally conductive surface by: (i) the rapid drop in the temperature of the cooling device between approximately -10 ° C and approximately -50 ° C, in no more than 5 minutes , in order to form a thin layer of gel / solution of biocompatible polymer frozen on the thermally conductive surface; (ii) the rapid rise of the temperature of the cooling device, in no more than 5 minutes, at a temperature closer to but still less than Tm; (iii) the gradual reduction of the temperature of the cooling device to induce a constant unidirectional growth rate of ice crystals in the biocompatible gel / polymer solution, initiated from the frozen layer formed in step c (i); and d. lyophilize the product from step c (iii).Un método para producir un material poroso a partir de una solución líquida que comprende un polímero biocompatible, comprendiendo el método: a. introducir la solución de polímero biocompatible en un recipiente térmicamente aislado con una superficie térmicamente conductora; b. opcionalmente, permitir que al menos parte de la solución de polímero biocompatible se gelifique, enfriando el recipiente en un dispositivo de enfriamiento a una temperatura en el intervalo desde el punto de fusión de la muestra (Tm) hasta 25 ºC; c. congelar el gel/solución de polímero biocompatible de manera controlada a través de la superficie térmicamente conductora mediante: (i) la caída rápida de la temperatura del dispositivo de enfriamiento entre aproximad
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