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INHIBITEUR DES TRANSPORTEURS SODIUM/GLUCOSE, SON PROCÉDÉ DE PRÉPARATION ET SON UTILISATION
专利权人:
LTD.;BEIJING PRELUDE PHARM. SCI.& TECH. CO.
发明人:
WANG, MICHAEL
申请号:
EP12775960
公开号:
EP2703396A4
申请日:
2012.02.20
申请国别(地区):
EP
年份:
2014
代理人:
摘要:
Disclosed is a compound of formula I, or a pharmaceutically acceptable salt, solvate, polymorph, enantiomer or racemic mixture thereof, wherein R1 and R2 are each independently hydrogen, -OH, alkyl, -CF 3 , -OCHF 2 , -OCF 3 or halogen; R3 is cycloalkyl, -OCH 2 CF 3 , -OCH 2 CHF 2 , -OCH 2 CH 2 F or -OCH 2 CH 3 ; R4 is hydrogen, -OH, -O aryl, -OCH 2 aryl, alkyl, cycloalkyl, -CF 3 , -OCHF 2 , -OCF 3 , -OCH 2 CF 3 , -OCH 2 CHF 2 , -OCH 2 CH 2 F or halogen; A is -CX 1 X 2 , wherein X 1 and X 2 are each independently H, F and Cl, and when both X 1 and X 2 are H, R3 is not -OCH 2 CH 3 . The compound has an activity of inhibitors of sodium-dependent glucose transport protein. Also disclosed is a method for preparing the compound, a pharmaceutical composition comprising the compound, use of the compound and pharmaceutical composition thereof in preparing medicaments of SGLT2 inhibitors and treating related diseases.
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