O'BRIEN, EDWARD R. M.,SHI, CHUNHUA,CHEN, YONG-XIANG,OBRIEN, EDWARD R. M.
申请号：
CA2997683
公开号：
CA2997683A1
申请日:
2016.08.29
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
The patent application pertains to compositions and methods for reducing Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) expression and for reducing serum cholesterol in mammalian subjects. The exemplary compositions comprise heat shock protein HSP27 or fragments thereof and/or a HSP25, or fragments thereof in a mixture with an adjuvant. The compositions may optionally comprise anti-HSP27 antibody. The method for reducing serum cholesterol relate to the use of the compositions to increase the subject's levels of serum HSP27 and/or anti-HSP27 antibodies.
