Chong-Pyoung Chung;Sang Hoon Rhee;Jue- Yeon Lee;Yoon-Jeong Park
发明人:
Chong-Pyoung Chung,Yoon-Jeong Park,Sang Hoon Rhee,Jue- Yeon Lee
申请号：
US13821811
公开号：
US20130210736A1
申请日:
2011.03.09
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a peptide having bone tissue regeneration capacity and binding to surface of apatite, and more particularly, to a peptide having bone tissue regeneration capacity and specifically binding to a surface of apatite mineral, capable of being stably immobilized to the surface of apatite mineral to retain effective activity and exhibit bone regeneration effects for a long time, by linking an amino acid sequence having bone tissue regeneration capacity and an amino acid sequence having apatite-binding capacity to each other to thereby provide a peptide having both bone-forming effects and binding capacity to the surface of apatite mineral, and a composition for bone tissue regeneration, containing the peptide. The peptide having binding capacity to the apatite mineral and bone tissue regeneration capacity according to the present invention binds to the surface of apatite to thereby be present in a stable state, and thus can be used in a bone replacement material for dental or orthopedic application, and metal, natural polymers, or synthetic polymers, coated with apatite； promote transition, proliferation, and differentiation of cells associated with regeneration and eventually maximize bone tissue regeneration； and can be stably present while maintaining peptide activity when being grafted into the body and thus is useful in development of the bone tissue regeneration therapeutic technology using the peptide.
