The invention provides a method for guiding the acquisition of an ultrasound image. A 3D ultrasound image is acquired by an ultrasound probe at a first position and an anatomical structure is identified within the 3D ultrasound image. A target imaging plane is estimated based on the identified anatomical structure and it is determined whether the target imaging plane is present within the 3D ultrasound image. If the target imaging plane is present, a displacement between a central plane of the 3D ultrasound image and the target plane is determined. If the displacement is below a predetermined threshold, the target imaging plane is extracted and if the displacement is above the predetermined threshold, an instruction to acquire a 3D ultrasound image with the ultrasound probe at a second position, different from the first positon, is generated based on the displacementThe invention further provides a method for estimating a target imaging plane. A central plane of a 3D ultrasound image is obtained, wherein the central plane contains at least part of an anatomical structure and a bounding box is generated around the anatomical structure. The bounding box is divided into a grid having a plurality of grid points and, for each grid point； an offset is estimated between the central plane and an optimal imaging plane. Finally, coordinates of the target imaging plane are estimated based on the offset for each grid point of the bounding box.
