モンテルカストジプロピルアミン塩の結晶を製造する方法

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专利权人:

株式会社トクヤマ

发明人:

志水 朋洋,神薗 弘行,小林 健介

申请号：

JP2013210214

公开号：

JP6227963B2

申请日:

2013.10.07

申请国别(地区):

JP

年份:

2017

代理人:

摘要：

PROBLEM TO BE SOLVED: To provide a method for efficiently manufacturing dipropylamine 1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methylcyclopropaneacetate by reacting dipropylamine with a crude form of 1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methylcyclopropaneacetic acid.SOLUTION: When synthesizing dipropylamine 1-(((1(R)-(3-(2(E)-(7-chloro-2-quinolinyl)ethenyl)phenyl)-3-(2-(1-hydroxy-1-methylethyl)phenyl)propyl)thio)methylcyclopropaneacetate, a solvent mixture of butyl acetate and a hydrocarbon having 5-7 carbon atoms is used as a solvent, and crystals are deposited from a solution.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/