Show-Wen Liu,Cheng-Hsien Lin,Yu Chang,Cheng-Fang Hsu,Tsyh-Lang Lin
申请号：
US13087664
公开号：
US08551447B2
申请日:
2011.04.15
申请国别(地区):
US
年份:
2013
代理人:
摘要：
A bifunctional compound with a monosaccharide and a N2S2 ligand, and more particularly, a bifunctional compound with a N2S2 ligand and aminohexylacetyl galactosamine (ah-GalNAc4) is provided. A method for preparing the bifunctional compound with a monosaccharide and a N2S2 ligand is also provided, including activating a carboxyl group in an organic ligand, reacting the activated carboxyl group with a galactopyranoside through amidation, and then hydrolyzing. The bifunctional compound of the present invention is widely useful in nuclear medicine for preparation of liver imaging agents for assisting in correct diagnosis of diseases.
