PROBLEM TO BE SOLVED: To provide a method for producing a differentiation-induced cell population from which undifferentiated cells are removed.SOLUTION: According to the present invention, there is provided a method for producing a cell population containing differentiated cells obtainable by inducing differentiation of pluripotent stem cells. Here, the method comprises, in the presence of a BET inhibitor, which is a histone acetylation inhibitor, and a CDK inhibitor, culturing a cell population containing differentiated cells that can be obtained by differentiation induction of pluripotent stem cells, which are artificial pluripotent stem cells or embryonic stem cells, to reduce the content of undifferentiated pluripotent stem cells.SELECTED DRAWING: NoneCOPYRIGHT: (C)2018,JPO&INPIT【課題】未分化細胞が除去された分化誘導細胞集団の製造方法の提供。【解決手段】多能性幹細胞を分化誘導することにより得られうる分化細胞を含有する細胞集団の製造方法であって、ヒストンアセチル化阻害剤であるBET阻害剤、及びCDK阻害剤の存在下で、人工多能性幹細胞又は胚性幹細胞である多能性幹細胞を分化誘導することにより得られうる分化細胞を含有する細胞集団を培養することにより、未分化多能性幹細胞の含有割合を低減する工程を含む、製造方法。【選択図】なし
