KOREA INSTITUTE OF RADIOLOGICAL & MEDICAL SCIENCES
发明人:
PARK, JI AE,박지애,KIM, JUNG YOUNG,김정영,LEE, KYO CHUL,이교철,LEE, YONG JIN,이용진,CHOI, JAE YONG,최재용,KIM, KYEONG MIN,김경민
申请号：
KR1020170101351
公开号：
KR1019182050000B1
申请日:
2017.08.09
申请国别(地区):
KR
年份:
2018
代理人:
摘要：
According to one aspect of the present invention, provided is a compound represented by chemical formula I, having a structure in which a tumor-selective arginylglycylaspartic acid (Arg-Gly-Asp, RGD) peptide and a ligand for radioactive isotope labeling are each covalently bonded to amines on both sides of 2,2′-diaminobiphenyl. Moreover, provided are a compound which is for radiopharmaceutical products and to which a radioisotope is bound to the compound, a method for producing the compound for radiopharmaceutical products, and a radiopharmaceutical product containing the compound for radiopharmaceutical products.본 발명의 일 양상은 종양 선택성 RGD 펩티드 및 방사성동위원소 표지용 리간드가 2,2'-디아미노바이페닐의 양쪽의 아민에 각각 공유결합된 구조를 갖는 화학식 I의 화합물, 그 화합물에 방사성동위원소가 결합된 방사성의약품용 화합물, 그 방사성의약품용 화합물의 제조방법, 및 그 방사성의약품용 화합물을 포함하는 방사성의약품을 제공한다.
