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Methods and Compositions for Treatment of Interferon-Resistant Tumors
专利权人:
Canji Inc.
发明人:
William F. BENEDICT
申请号:
US16214180
公开号:
US20190374654A1
申请日:
2018.12.10
申请国别(地区):
US
年份:
2019
代理人:
摘要:
The present invention provides a method for the treatment of “interferon resistant” tumors (i.e., tumors resistant to treatment with exogenously-administered interferon polypeptide) through the use of a non-replicating agent which induces human cells to express interferon species. In particular it is noted that inducing interferon expression in the patient's body possesses properties not associated with exogenously-produced intravenously-administered interferon proteins. The present invention further provides compositions useful in the treatment of cancer resistant to treatment with exogenous interferon polypeptide, by using a non-replicating agent which induces human cells to express interferon species, e.g., an antigenic, replication-deficient virus optionally carrying an interferon transgene.
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