The present invention relates to pyrrolo[3,2-c]pyridine-4-one 2-indolinonecompounds of Formula (I) and their pharmaceutically acceptable salts thereof,wherein R1, R2, R3, R4, R5, R6, R7, R8 X , Y and ~. have the meaning cited inthe specification. Also disclosed are the pharmaceutical compositionscontaining the foregoing compounds, methods for the preparation andpharmaceutical use thereof, particularly as protein kinase inhibitors. Formula(I).