abstract disclosed are double stranded rna molecules that are toxic to coleopteran insects. in particular, molecules that are capable of interfering with pest genes and which are toxic to the target pest are provided. further, methods of making and using interfering rna, for example in transgenic plants to confer protection from insect damage are disclosed. abstract of patent summary: "biological control of beetle pests". Double-stranded RNA molecules are disclosed that are toxic to Coleoptera insects. in particular, dsrna molecules are provided which are capable of interfering with pest iap genes and which are toxic to the target pest. In addition, methods for preparing and using interfering RNA, for example in transgenic plants, to provide protection against insect damage are disclosed.abstract disclosed are double stranded rna molecules that are toxic to coleopteran insects. in particular, dsrna molecules that capable of interfering with pest iap genes and that are toxic to the target pest are provided. further, methods of making and using the interfering rna, for example in transgenic plants to confer protection from insect damage are disclosed. tradução do resumo resumo patente de invenção: "controle biológico de pragas de coleópteros". são reveladas moléculas de rna de fita dupla que são tóxicas para insetos coleópteros. em particular, são proporcionadas moléculas de dsrna que são capazes de interferir em genes iap de pragas e que são tóxicas para a praga-alvo. adicionalmente, são revelados métodos de preparação e uso do rna interferente, por exemplo, em plantas transgênicas, para conferir proteção contra danos causados por insetos.
