The Charles Stark Draper Laboratory, Inc.;Johnson & Johnson Innovation LLC
发明人:
Joseph L. Charest,Martin Nohilly,Christopher Dibiasio,Jeffrey T. Borenstein,Mark Laurenzi,Jonathan Wilson
申请号：
US15046152
公开号：
US20160158428A1
申请日:
2016.02.17
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A microfluidic device for increasing convective clearance of particles from a fluid is provided. In some implementations, described herein the microfluidic device includes multiple layers that each define infusate, blood, and filtrate channels. Each of the channels have a pressure profile. The device can also include one or more pressure control features. The pressure control feature controls a difference between the pressure profiles along a length of the device. For example, the pressure control feature can control the difference between the pressure profile of the filtrate channel and the pressure profile of the blood channel. In some implementations, the pressure control feature controls the pressure difference between two channels such that the difference varies along the length of the channels by less than 50% of the pressure difference between the channels at the channels' inlets.
