Solid oral pharmaceutical formulation containing ticagrelor

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专利权人:

ゼンティーバ，カー．エス．;ゼンティーバ,カー.エス.

发明人:

グレゴル セドマク

申请号：

JP2015535983

公开号：

JP6301934B2

申请日:

2013.10.15

申请国别(地区):

JP

年份:

2018

代理人:

摘要：

The present solution provides a solid oral pharmaceutical formulation containing ticagrelor, in the chemical name (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]- 5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2- cyclopentanediol, comprising at least one non-hygroscopic filler and/or at least one non- hygroscopic binder, wherein neither the filler, nor the binder have any disintegration effect. Preparation of the formulation is possible by wet granulation or dry granulation or direct

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