The present invention is related to a method for risk detection, diagnosis, prognosis and monitoring of Alzheimers disease (AD). The method comprises the steps of: (1) measuring the level of glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in a sample from the subject, and (2) comparing the level of GAPDH in the sample with two or more AD reference levels of GAPDH.本發明係關於一種用於阿茲海默症(Alzheimers disease;AD)風險偵測、診斷、預後及監控的方法。該方法包含的步驟有:(1) 測量來自個體之一樣本中的甘油醛-3-磷酸去氫酶(GAPDH)量,以及(2) 將該樣本中之GAPDH量與GAPDH之兩個或多個AD參考量相比較。