UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION
发明人:
DELGOFFE, GREG M.,RIVADENEIRA, DAYANA,SAMPATH, PADMAVATHI,THORNE, STEPHEN H.
申请号：
CA3087044
公开号：
CA3087044A1
申请日:
2019.01.28
申请国别(地区):
CA
年份:
2019
代理人:
摘要：
Recombinant oncolytic viruses (OVs) that express one or more metabolic modulator proteins, such as an adipokine (e.g., leptin or chemerin), insulin, and/or IGF- 1, and methods of their use to treat cancer, for example in immunotherapy anti-cancer treatments. In some examples, such recombinant OVs and methods increase T cell infiltration into the tumor or tumor microenvironment.
