Antibodies directed against ICOS and uses thereof

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专利权人:

Julien Faget;Christine Menetrier-Caux;Daniel Olive;Christophe Caux;Jacques Nunes

发明人:

Julien Faget,Christophe Caux,Christine Menetrier-Caux,Jacques Nunes,Daniel Olive

申请号：

US14008423

公开号：

US09376493B2

申请日:

2012.03.29

申请国别(地区):

US

年份:

2016

代理人:

摘要：

The present invention provides antibodies directed against ICOS or a derivative thereof which neutralize ICOS engagement on Treg by inhibiting the fixation between ICOS and ICOS-L and abrogate proliferation of Treg induced by plasmacytoid dendritic cells. The present invention further provides antibodies directed against ICOS or a derivative thereof which induce IL-10 and IFNγ production, induce CD4+ T cells proliferation, reduce Tconv proliferation, and increase the immunosuppressive function of Treg.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/