您的位置: 首页 > 农业专利 > 详情页

用於確定抵抗雄激素受體療法的方法和組合物
专利权人:
ARAGON PHARMACEUTICALS INC.
发明人:
JAMES DAVID JOSEPH,JEFFREY H. HAGER,JOHN, LEE SENSINTAFFAR,NHIN LU,JING QIAN,NICHOLAS, D. SMITH
申请号:
HK15111856.3
公开号:
HK1211060A
申请日:
2015.12.02
申请国别(地区):
HK
年份:
2016
代理人:
摘要:
Described herein are modified androgen receptor polypeptides that are resistant to inhibition by an androgen receptor inhibitor. Described herein are compositions, combinations, and kits containing the modified androgen receptor polypeptides and methods of using the modified androgen receptor polypeptides. Also described herein are methods of using the modified androgen receptor polypeptides as screening agents for the identification and design of third-generation androgen receptor modulators. Also described herein are third-generation androgen receptor modulators that inhibit the activity of the modified androgen receptor polypeptides. Also described are pharmaceutical compositions and medicaments that include the compounds described herein, as well as methods of using such androgen receptor modulators, alone and in combination with other compounds, for treating diseases or conditions, including cancers, such as castration resistant prostate cancers, that are mediated or dependent upon androgen receptors.
来源网站:
中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

意 见 箱

匿名:登录

个人用户登录

找回密码

第三方账号登录

忘记密码

个人用户注册

必须为有效邮箱
6~16位数字与字母组合
6~16位数字与字母组合
请输入正确的手机号码

信息补充