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Lentiviral vectors pseudotyped with mutant BaEV glycoproteins
专利权人:
Anais Girard-Gagnepain
发明人:
Anais Girard-Gagnepain,Els Verhoeyen,Dimitri Lavillette,Francois-Loic Cosset
申请号:
US14346357
公开号:
US09249426B2
申请日:
2012.09.28
申请国别(地区):
US
年份:
2016
代理人:
摘要:
The present invention concerns a pseudotyped viral vector particle for transferring biological material into cells, wherein said vector particle comprises at least:—a chimeric envelope glycoprotein which comprises or consists in a fusion of the transmembrane and extracellular domain of a baboon endogenous retrovirus (BaEV) envelope glycoprotein and the cytoplasmic tail domain of a murine leukemia virus (MLV) envelope glycoprotein or—a modified BaEV envelope glycoprotein wherein the cytoplasmic tail domain is devoid of the fusion inhibitory R peptide.
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